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The carboxy-terminal region of dystrophin has previously been shown to interact directly with α1 syntrophin, a cytoplasmic component of the dystrophin-glycoprotein complex, by in vitro biochemical studies such as overlay assay or immunoprecipitation. Using the two-hybrid system, we have isolated from a human heart cDNA library the entire coding sequence of human α1 syntrophin, therefore confirming...
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