Titanate nanomesh layers were fabricated on Ti-based bulk metallic glass (BMG) to induce bioactivity in the form of apatite-forming ability. Titanate nanomesh layers were prepared by hydrothermal–electrochemical treatment at 90°C for 2h, with an aqueous solution of NaOH as an electrolyte. A constant electric current of 0.5mAcm −2 was applied between the BMG substrate and a Pt electrode acting as the anode and cathode, respectively. A nanomesh layer, consisting of nanowires (∼20nm in diameter) formed on the BMG. An immersion test in simulated body fluid for 12 days revealed that the titanate nanomesh layer on the BMG promoted the growth of bone-like hydroxyapatite.