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Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fyn z /fyn z ) mice exhibited stronger light aversion in the light--dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+ /fyn z ) mice. These results indicate that fyn z /fyn z mice are hyperresponsive to fear-inducing stimuli.