The roots, leaves, seeds and fruits (berries) of the solanaceous plants such as Atropa belladona L., Hyosciamus niger L., Hyosciamus Albus L., Datura stramonium L., and Datura sauveolens L, have in their composition the atropine and scopolamine alkaloids. The lethal doses of these compounds are lower than 10 mg for children. The berries are very attractive for them. Although 20 to 30 berries are reported as the lethal dose, one half of a berry may be susceptible to cause the death of children.Since the beginning of the XIX century, we have the knowledge of the fatal and non-fatal intoxications by solanaceous plants, namely by berries of belladonna.In a search of 22 cases of hospitalization due to plants in the central zone of Portugal, 16 cases were related to solanaceous plants by ingestion of their berries. The symptoms presented were, in general, dry skin and mouth, dilated pupils, ataxy and great excitation. In some cases hallucinations, delirium and confusion were reported.The sensitive GC/MS, mode SIM, method that was developed in our laboratory was used for atropine and scopolamine determination in plasma and urine. The extraction was performed under alkaline conditions with chloroform: isopropanal and the derivatization with pentafluoropropionic anhydride. In the quantification, we used nalorphine as the internal standard. The limit of quantification was approximately 15 ng/ml for atropine and 20 ng/ml for scopolamine. The variation coefficients were under 10%.