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Les mutations germinales deleteres des genes BRCA 1 & 2 exposent a des risques de cancer mammaire et ovarien (risques cumules respectifs de 37 a 85 % et 10 a 20 %) chez des femmes jeunes et posent des problemes gynecologiques specifiques allant de la chirurgie prophylactique aux traitements hormonaux. Les auteurs presentent les observations de deux soeurs porteuses d'une mutation BRCA 1 (exon...
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