Two new sesquiterpenoids with the guaiane and eudesmane carbon skeleton termed pancherione and eudesm-4(14)-en-3α, 11-diol, were isolated from the heartwood of Neocallitropsis pancheri and characterized by 1D and 2D NMR spectroscopy. Trans-dihydrocarissone and α-, β- and γ-costols were also obtained from this plant for the first time and their NMR parameters are given.