Efficacy of radiotherapy for epithelial skin cancer was evaluated and treatment outcomes of two electron beam fractionation schedules were compared.Outcome data of 434 epithelial skin cancers in 333 patients were analysed; 332 were basal cell carcinomas (BCCs) and 102 squamous cell carcinomas (SCCs). Patients were treated with electron beam, and received either 54Gy in 18 fractions (n=159) or 44Gy in 10 fractions (n=275). Local recurrence free (LRF) rates were analysed as well as metastases free rates, cancer specific survival (CSS) and cosmetic result.Median follow-up was 42.8months. For BCC, actuarial 3-year LRF rates were 97.6% for tumours treated with 54Gy and 96.9% for 44Gy. In SCC 3-year LRF rates were 97.0% for 54Gy and 93.6% for 44Gy (n.s.).T stage was found to be the only significant factor for recurrence (p=0.036). Three-year CSS was 98% for SCC and 100% for BCC.Electron beam irradiation is a safe and effective treatment modality for epithelial skin cancer. In view of a similar efficacy and patient convenience of the hypofractionated schedule, 44Gy in 10 fractions can be regarded the radiation schedule of choice.