The article covers the methodology used to design safety control systems for unattended points of technological communication on oil and gas pipelines; it gives the review of safety control system design, the relevance of the researched area and research methods; it describes the structure of an unattended point of technological communication, specific hazardous factors, affecting factors; the article focuses on the possible safety system structures, suggests the ways to select the necessary safety system structure, the design of its central block and qualitative content of information sources on hazardous factors; it describes the mathematical model for quantitative safety assessment, and shows the results of the research outcome implementation in the safety systems in operation.