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The purpose of the study was to incorporate estradiol into in situ gelling nasal inserts by complexation with methyl-β-cyclodextrin (MβCD) and to evaluate the in vivo performance of estradiol-loaded inserts, solutions, and microparticles in rats. Aqueous solutions of estradiol/MβCD complexes and hydrophilic polymers (carrageenan, sodium alginate, HPMC, PVP 90, and xanthan gum) were freeze-dried to...
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