PURPOSE: To evaluate the safety and outcome of laser in situ keratomileusis in eyes with inactive herpetic keratitis.METHODS: Prospective, interventional case series. In three eyes of three patients with inactive unilateral herpetic keratitis for a minimum period of 1 year, laser in situ keratomileusis was performed. Oral and topical acyclovir were prescribed perioperatively. No topical steroids were prescribed.RESULTS: Preoperatively, all three eyes had corneal stromal scars with induced astigmatism in two eyes and central stromal scar in one eye with best-corrected visual acuity of 20/120, 20/25, and 20/50, respectively. Postoperatively, the three eyes achieved uncorrected visual acuity of 20/20, 20/20, and 20/50, respectively, with decreased corneal scar. None of the patients developed herpetic keratitis reactivation during a minimum follow-up of 6 months.CONCLUSION: Laser in situ keratomileusis was safe and effective in the treatment of refractive errors and corneal scars in three eyes of three patients with inactive herpetic keratitis.