In this paper, we are mainly interested in inference on the reliability coefficient, R=P(X<Y), in proportional odds ratio models based on the new family of tilted survival functions introduced by Marshall and Olkin [Marshall, A.W., Olkin, I., 1997. A new method for adding a parameter to a family of distributions with application to the exponential and Weibull families. Biometrika 84 (3), 641–652]. We also present some results on stochastic comparison between the survival distribution functions. Asymptotic and various bootstrap confidence intervals of R are investigated. The performance of asymptotic and bootstrap confidence intervals is studied through a simulation. A numerical example based on real-life data is presented to illustrate the implementation of the proposed procedure.