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Primary biliary cirrhosis (PBC) is a chronic liver disease characterized by progressive hepatic fibrosis. Fibroproliferation is one of two major events occurring in hepatic fibrosis. In this study we evaluated PBC patients sera samples (n = 27) and our results demonstrate that the sera of PBC patients has fibroproliferative activity. Our results further demonstrate that this effect is partially mediated...
The efficacy of Interferon (IFN) therapy against hepatitis C is greatly affected by viral factors such as the level of viremia and the HCV genotype. The prognosis of those with high serum HCV-RNA levels in genotype 1b is poor. In the present report, we carried out a randomized controlled study of two IFN doses for patients with genotype 1b chronic hepatitis C whose serum HCV-RNA levels were at least...
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