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The diagnosis of poisoning is often obvious (e.g. in a patient presenting with drug overdose), but can sometimes be more challenging. This article describes some clinical presentations where poisoning should be considered in the differential diagnosis. These are unexplained coma or confusion, hypoglycaemia, abnormal liver function, unexplained convulsions, metabolic acidosis and abnormal bleeding...
Biochemical and metabolic abnormalities commonly arise in any critically ill patient and in poisoning as a result of an effect of the poison on a particular metabolic pathway or due to poison-induced organ dysfunction. The management of biochemical abnormalities is an essential part of the supportive care of severely poisoned patients, and may be of diagnostic or prognostic value. Acid–base abnormalities...
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