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Adverse drug effects on the gastrointestinal (GI) tract can occur as a predictable result of a drug’s mode of action, by direct injury, through compromising GI defences, or as a consequence of changes in colonic bacterial flora. Non-steroidal anti-inflammatory drugs (NSAIDs) are the commonest cause of gastroduodenal injury, owing to inhibition of prostaglandin synthesis, and increase the risk of serious...
Chronic kidney disease (CKD) is accompanied by tubulo-interstitial atrophy and fibrosis, regardless of the underlying cause. Disorders of the renal vasculature, the glomeruli or urinary drainage all culminate in chronic tubulo-interstitial damage, the severity of which is the histological feature that correlates best with progression to end-stage renal failure (ESRF). However, there are diverse conditions...
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