Journal of Pharmacological Sciences

Items from 1 to 12 out of 12 results

article

Effects of l-tryptophan on gastric emptying evaluated by breath test in relation to gastric accommodation evaluated by Barostat in rats

Masayuki Uchida, Orie Kobayashi, Chizuru Iwamoto

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 229-231

Gastric emptying has been known to correlate the pyloric sphincter contractile function and distention-induced gastric relaxation (gastric accommodation). In the present study, the effects of l-tryptophan on the gastric emptying and accommodation were evaluated by breath test using [1- ¹³ C]acetic acid and Barostat study, respectively, in rats. l-Tryptophan significantly decreased Cmax and...

article

Myeloid HIF-1 attenuates the progression of renal fibrosis in murine obstructive nephropathy

Yu Tateishi, Mayuko Osada-Oka, Masako Tanaka, Masayuki Shiota, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 181-189

Hypoxia-inducible factors (HIFs) play an important role in the pathogenesis of renal fibrosis. Although the role of macrophage infiltration in the progression of renal fibrosis is well known, the role of macrophage HIF-1 remains to be revealed. To address this question, myeloid specific conditional HIF-1 knock out mice were subjected to unilateral ureteral obstruction (UUO). Renal interstitial deposition...

article

Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

Musen Lin, Xiaohan Zhai, Guangzhi Wang, Xiaofeng Tian, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 203-210

Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia miltiorrhiza, has well-known antioxidant and anti-inflammatory actions. We aimed to evaluate the ability of SalB to protect against APAP-induced acute...

article

Target-mediated pharmacokinetic/pharmacodynamic model based meta-analysis and dosing regimen optimization of a long-acting release formulation of exenatide in patients with type 2 diabetes mellitus

Hanqing Li, Jiayin Xu, Xiaohong Fan

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 170-180

A hybrid pharmacokinetic/pharmacodynamic (PK/PD) model with extended-release (ER) process and target mediated drug disposition (TMDD) was developed for exenatide ER to account for its complex absorption process and glucagon-like peptide 1 receptor (GLP-1R)-mediated non-linear PK behaviors along with its influences to fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c). Using hybrid PK/PD model,...

article

Impaired retinal vasodilator response to acetylcholine in a rat model of NMDA-induced retinal degeneration

Asami Mori, Masayuki Hanada, Kenji Sakamoto, Tsutomu Nakahara, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 211-216

Previous studies have shown that degeneration of retinal capillaries occurs following N-methyl-d-aspartate (NMDA)-induced retinal neurotoxicity, but it is unclear whether vasodilatory mechanisms are altered in retinal blood vessels. The purpose of the present study was to determine whether retinal vasodilator responses are affected in a rat model of NMDA-induced retinal damage. At 14 days after a...

article

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice

Shigeru Hasebe, Naoki Hiramatsu, Yukio Ago, Kazuya Mori, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 232-235

We have found that fluvoxamine-induced increases in prefrontal dopamine release are enhanced by adrenalectomy/castration and 5-HT _1A receptors are involved in the enhancement. This study examined which 5-HT _1A autoreceptors or postsynaptic receptor play a key role in the enhancement in mice. Adrenalectomy/castration-induced enhancement of fluvoxamine-induced increase in the dopamine...

article

Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects

Katsuhiko Noguchi, Toshihiro Matsuzaki, Mayuko Sakanashi, Naobumi Hamadate, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 217-222

Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in healthy subjects.A double-blind, placebo-controlled, crossover study was performed...

article

Population pharmacokinetics and dosing simulations of imipenem in serious bacteraemia in immunocompromised patients with febrile neutropenia

Sutep Jaruratanasirikul, Wibul Wongpoowarak, Monchana Jullangkoon, Maseetoh Samaeng

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 164-169

The aims of this study were to i) reveal the population pharmacokinetics; and ii) assess the probability of target attainment (PTA) and cumulative fraction of response (CFR) (defined as the expected population PTA for a specific drug dose and a specific population of microorganisms) of imipenem in febrile neutropenic patients with bacteraemia. Ten patients were randomised into two groups: Group I...

article

Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease

Masaaki Akagi, Nobuaki Matsui, Haruka Akae, Nana Hirashima, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 155-163

Developed regions, including Japan, have become “aged societies,” and the number of adults with senile dementias, such as Alzheimer's disease (AD), Parkinson's disease, and Huntington's disease, has also increased in such regions. Neurotrophins (NTs) may play a role in the treatment of AD because endogenous neurotrophic factors (NFs) prevent neuronal death. However, peptidyl compounds have been unable...

article

Interaction of rocuronium with human liver cytochromes P450

Eva Anzenbacherova, Alena Spicakova, Lenka Jourova, Jitka Ulrichova, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 190-195

Rocuronium is a neuromuscular blocking agent acting as a competitive antagonist of acetylcholine. Results of an inhibition of eight individual liver microsomal cytochromes P450 (CYP) are presented. As the patients are routinely premedicated with diazepam, possible interaction of diazepam with rocuronium has been also studied.Results indicated that rocuronium interacts with human liver microsomal CYPs...

article

Salinomycin causes dedifferentiation via the extracellular signal-regulated kinase (ERK) pathway in rabbit articular chondrocytes

Seon-Mi Yu, Song-Ja Kim

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 196-202

Salinomycin (SAL), a monocarboxylic polyether antibiotic isolated from Streptomyces albus, modulates various cellular responses, including proliferation, apoptosis, and inflammation. However, the effect of SAL on the dedifferentiation of chondrocytes remains unclear. Thus, we investigated the effects and regulatory mechanisms of SAL on the dedifferentiation of rabbit articular chondrocytes. Our results...

article

Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice

Masahiro Murakami-Nakayama, Maho Tsubota, Saki Hiruma, Fumiko Sekiguchi, more

Journal of Pharmacological Sciences > 2015 > 127 > 2 > 223-228

Ca _v 3.2 T-type Ca ²⁺ channels targeted by H ₂ S, a gasotransmitter, participate in cyclophosphamide-induced cystitis and bladder pain. Given that zinc selectively inhibits Ca _v 3.2 among T-channel isoforms and also exhibits antioxidant activity, we examined whether polaprezinc (zinc-l-carnosine), a medicine for peptic ulcer treatment and zinc supplementation, reveals...

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Volume:
127
Year:
2015

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Keywords

PHARMACODYNAMICS (2)
5-HT1A AUTORECEPTOR (1)
ACETAMINOPHEN HEPATOTOXICITY (1)
ANTIOXIDANT ACTIVITY (1)
BLADDER PAIN (1)
CAFFEINE (1)
CHONDROCYTES (1)
COFFEE (1)
CYCLOPHOSPHAMIDE-INDUCED CYSTITIS (1)
CYTOCHROME P450 (1)
DOSING REGIMENS (1)
DRUG INTERACTIONS (1)
ENDOTHELIAL CELL (1)
ENDOTHELIAL FUNCTION (1)
EXCITOTOXICITY (1)
EXENATIDE EXTENDED-RELEASE (1)
EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) (1)
FEBRILE NEUTROPENIA (1)
GASTRIC ACCOMMODATION IN RAT (1)
GASTRIC EMPTYING (1)
HYPOXIA-INDUCIBLE FACTOR (1)
IMIPENEM (1)
L-TRYPTOPHAN (1)
LASER-DOPPLER FLOWMETRY (1)
MACROPHAGE (1)
MICROCIRCULATION (1)
MODEL BASED META-ANALYSIS (1)
NATURAL PRODUCTS (1)
NONPEPTIDE NEUROTROPHIC AGENTS (1)
NRF2 (1)
PHARMACOKINETICS (1)
PHARMACOKINETICS/PHARMACODYNAMICS (1)
PHASE II ENZYME (1)
PI3K (1)
PKC (1)
POLAPREZINC (1)
POPULATION PHARMACOKINETICS (1)
PREFRONTAL DOPAMINE RELEASE (1)
RAT CORTICAL NEURONS (1)
RENAL FIBROSIS (1)
RETINAL BLOOD VESSEL (1)
RETINAL NEURONAL CELL (1)
ROCURONIUM (1)
SALINOMYCIN (SAL) (1)
SALVIANOLIC ACID B (SALB) (1)
SENESCENCE-ACCELERATED MICE (1)
T-TYPE CA2+ CHANNEL (1)
VASODILATION (1)
WAY100635 (1)
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