This paper deals with cementation as the method for the disposal of spent biosorbent,Ganoderma lucidum (a wood rotting macrofungi) after it is used for the removal of Uranium. Results on the uranium release during the curing of cement - concrete (CC) blocks indicated that placing the spent sorbent at the centre of the blocks during their casting yields better immobilization of uranium as compared to the homogeneous mixing of the spent sorbent with the cement. Short term leach tests indicated that the uranium release was negligible in simulated seawater, 1.8% in 0.2 N sodium carbonate and 6.0% in 0.2 N HCl. The latter two leachates were used to represent the extreme environmental conditions. It was observed that the presence of the spent biosorbent up to 5% by weight did not affect the compressive strength of CC blocks. Thus cementation technique is suitable for the immobilization of uranium loaded biosorbent for its ultimate disposal.