Helping persons with severe mental illness cope with symptoms such as psychosis, negative symptoms, and mania is essential, but only part of the battle. Persons with mental illness also suffer from the negative effects of stigma, frequently encountering discrimination from landlords, employers, and neighbors. When clinicians fail to address stigma, they miss an opportunity to provide their clients with important strategies and skills. This paper responds to the five articles in this special series of Cognitive and Behavioral Practice, which focusses on issues related to stigma and mental illness. The author summarizes strategies in three categories of intervention: helping individuals to cope with stigma, empowering individuals to achieve their life goals, and changing society's attitudes. Some examples are given of programs that are implementing these strategies.