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Objectives. Prostate cancer detection in biopsies increases with the number of sites and total tissue sampled. Its dependence on needle core fragment length is uncertain.Methods. We surveyed two consecutive series of sextant needle biopsies from two practices in 1998 to 2000: 251 patients from Pennsylvania (group P) and 1596 from Virginia (group V). We tabulated the gross needle core lengths per sextant...
Objectives. To investigate the expression of hypoxia-inducible factor (HIF)-2α/endothelial PAS domain protein 1 (EPAS1) in bladder cancer.Methods. Two bladder cancer cell lines (T24, EJ-1) were examined for the expression of HIF-2α/EPAS1 mRNA by reverse transcriptase-polymerase chain reaction and HIF-2α/EPAS1 protein by Western blot analysis, respectively. Expression of HIF-2α/EPAS1 protein was also...
Objectives. To assess the prognostic value of flow cytometry and nuclear morphometry in prostate cancer after androgen deprivation treatment.Methods. A total of 127 patients with a prostate cancer diagnosis who had undergone androgen suppression were retrospectively studied. The DNA content by flow cytometry and nuclear morphometry was studied from biopsy specimens. In the patients with Stage M0,...
Objectives. To evaluate erectile dysfunction (ED) using a validated self-administered 5-item questionnaire (5-item version of the International Index of Erectile Function [IIEF-5]) and the use of sildenafil in community-dwelling older men.Methods. In October 1998, the IIEF-5 was mailed to all surviving members of an established community-based cohort of older men. The degree of ED was stratified by...
Objectives. Unusually high incidences of upper urinary tract urothelial carcinoma (UUT-UC) have been reported from the endemic area for ''blackfoot disease'' of southern Taiwan, and the arsenic-contaminated water was considered to be the reason for this prevalence. In this study, we determined the ratio of UC in different locations, the difference in clinical profiles for UUT-UC and urinary-bladder...
Objectives. To investigate the effect of varying levels of mechanical deformation (cyclic stretch-relaxation) on protein and DNA synthesis rates in human bladder smooth muscle cells (SMCs). Cells in the bladder wall respond to outlet obstruction by increasing rates of protein synthesis (''hypertrophy'') and/or DNA synthesis (''hyperplasia''); however, it is not established how these distinct processes...
Objectives. To review the pediatric renal trauma cases during the past 10 years to determine the appropriate indications for imaging and operative intervention.Methods. We searched the medical records from 1989 to 1999 and identified 61 patients aged up to 18 years old with objective data on renal trauma grade by either computed tomography or operative exploration and analyzed the data.Results. Of...
Objectives. To assess in a prospective study whether extracorporeal shock wave therapy (ESWT) using a standard radioscopic location lithotriptor is effective in the treatment of Peyronie's disease.Methods. Fifty-four patients were included in this prospective study. Before and after treatment, the angulation was calculated by auto-photography. Pain severity was assessed by a visual analog pain scale...
Objectives. To determine the probability of biochemical control for patients treated with salvage irradiation and identify prognostic factors associated with successful salvage. The optimal management of prostate cancer in patients with an elevated prostate-specific antigen (PSA) level after radical prostatectomy remains unclear.Methods. We reviewed the records of 54 patients with node-negative prostate...
A 38-year-old woman was found to have a squamous cell carcinoma in a urethral diverticulum after a simple diverticulectomy. The aggressiveness of this histologic subtype of carcinoma, along with this patient's long life expectancy, supported the choice of aggressive therapy. Only nine other cases have been reported. A brief review of the published reports on the presentation, diagnosis, options for...
Objectives. To report the use of a new acellular xenographic porcine jejunal submucosal graft as a closure material for tunica albuginea deficiencies (distal erosion, attenuation) after penile prosthesis insertion.Methods. Seventeen patients with at least a 36-month history of having an indwelling three-piece inflatable penile prosthesis developed tunica albuginea deficiencies. Nine patients with...
Objectives. To evaluate and compare the three commercially available first-generation hand-assisted laparoscopic (HAL) devices in a prospective, randomized fashion. HAL nephrectomy has become an increasingly popular surgical modality.Methods. Sixty-seven board-certified urologists each performed two HAL nephrectomies in a porcine laboratory, using two different hand devices, at a learning course sponsored...
Incontinence, impotence, and urethral stricture are reported complications of radical retropubic prostatectomy. Although complications are possible after urethroplasty for anterior urethral trauma as well, the combined risk in patients requiring this operation after radical retropubic prostatectomy is unknown. The first reported case involving the management of urethral trauma after radical prostatectomy...
Objectives. To determine the occurrence of clinically significant decreases in blood pressure (BP) with sildenafil use in normotensive and hypertensive men by means of ambulatory BP monitoring.Methods. On 2 nights, 49 men (22 hypertensive, 27 normotensive) had their ambulatory systolic BP (SBP), diastolic BP (DBP), and heart rate monitored during the first 3 hours (waking period) and every 30 minutes...
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