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To explore the significance of an E-cadherin gene promoter polymorphism for risk and disease severity of prostate cancer in a Japanese population.We enrolled 200 patients with sporadic prostate cancer and 159 control patients with benign prostatic hyperplasia in this case-control study. The −160C/A polymorphism in the E-cadherin gene promoter was genotyped by polymerase chain reaction–restriction...
During the preoperative evaluation of potential kidney donors, the increased sensitivity of spiral computed tomography (CT) could detect more asymptomatic small (less than 4 mm) renal calculi. However, whether these stones will be of consequence later has yet to be determined. We evaluated the rate of spontaneous passage, development of symptoms, and change in the size of asymptomatic renal calculi...
Interstitial transperineal cryoablation with 17-gauge cryoprobes is an accepted treatment modality for localized prostate cancer. The effectiveness of cryoablation in the treatment of local prostate cancer recurrence after radical retropubic prostatectomy (RRP) is unknown.We reviewed the outcome of cryoablative treatment in 15 patients for biopsy-proven locally recurrent prostate cancer after RRP...
Isolated polyarteritis nodosa is a rare condition that may be triggered by local exposure to certain agents capable of provoking local immunostimulation without a systemic immune reaction. Isolated polyarteritis nodosa in the testes presents similar histologic characteristics as those of systemic inflammation, although infarcted areas in the testis are more common in generalized polyarteritis nodosa...
To determine whether diet-induced diabetes mellitus (DM) in mice would reproduce the major features of human erectile dysfunction (ED) because DM is a significant risk factor in the development of ED.In total, 150 C57BL6 (bl6) mice were divided into six groups of 25 mice each. Of these 150 mice, 125 were fed a high-fat (45% of total calories) diet for the final 4 (group 2), 8 (group 3), 12 (group...
Ajulemic acid (IP-751) is a synthetic analog of tetrahydrocannabinol, which is a major ingredient of the plant Cannabis. IP-751 reportedly shows potent anti-inflammatory activity and is a powerful analgesic agent. Thus, we examined whether IP-751 can suppress urinary frequency induced by nociceptive stimuli in the bladder.Continuous cystometry (infusion rate 0.04 mL/min) under urethane anesthesia...
A recently described subtype of renal cell carcinoma (RCC) bearing chromosome translocations involving a breakpoint at Xp11 and resulting in gene fusions involving the TFE3 transcription factor gene often presents in the pediatric population. Herein we describe an Xp11 translocation RCC associated with prior exposure to cytotoxic chemotherapy, which massively recurred and led to the patient’s death...
Obesity, a significant risk factor for renal cell carcinoma (RCC), has recently become a public health problem in Japan. In addition, the incidence of RCC in Japan has steadily increased during the past few decades. The objective of the present study was to investigate the relationship of body mass index (BMI) to the prognosis of Japanese patients with RCC.From January 1991 to December 2002, 270 operations...
We previously reported the benefit of meticulous apical dissection in reducing positive surgical margins (SM+) at the apex. Herein we assess whether a more aggressive urethral transection will reduce positive margins and whether reduced urethral length affects return to continence.All data were collected prospectively. A positive surgical margin was defined by the presence of cancer cells with ink...
To report outcomes for localized prostate cancer patients treated with the combination of high-dose-rate (HDR) brachytherapy and external beam radiotherapy (EBRT).Eighty-five Stage T1c to T3b prostate cancer patients treated with HDR brachytherapy plus EBRT were included. An HDR dose of 16.5 Gy in 3 fractions over 24 hours was given 2 weeks before EBRT. An EBRT dose of 50.4 Gy was administered to...
To compare the coagulation depth and pathologic changes of the prostate after bipolar and monopolar transurethral resection of the prostate (TURP) in a canine model.The prostates of 25 dogs were treated in vivo with bipolar TURP (bipolar group, n = 12), monopolar TURP (monopolar group, n = 12), or sham operation (sham-operated group, n = 1). The prostate specimens were evaluated pathologically, and...
Adrenocortical carcinoma is a rare, highly malignant neoplasm that originates in the adrenal cortex and is difficult to differentiate from renal cell carcinoma, especially if it is gigantic and nonfunctional. We report the case of a 40-year-old man with an incidental mass in the right upper abdomen. Magnetic resonance imaging revealed that the mass originated from the right kidney and was highly suggestive...
To assess the efficacy and safety of helium as an insufflant for transabdominal laparoscopic renal surgery.The charts of all patients undergoing laparoscopic renal surgery with helium insufflation by a single physician between May 2003 and April 2006 were reviewed. Ventilatory parameters and postoperative recovery were reviewed.Ten patients underwent laparoscopic renal surgery with helium. These patients...
Percutaneous perineal cryoablation of the prostate is a promising technique in the treatment armamentarium for clinically localized prostate carcinoma. We report our initial experience using a transrectal ultrasound-guided, third-generation, argon/helium cryosurgical system.From January 2002 to July 2005, 50 men underwent primary cryosurgery for clinically localized prostate carcinoma. The median...
To develop a sensitive method for the detection of bladder cancer cells in the urine castoff cells of patients with bladder cancer, we examined the feasibility of using molecular beacon (MB) probes specific for tumor-specific survivin mRNA.MBs are single-stranded oligonucleotide hybridization probes that form a stem-and-loop structure and have high sensitivity and specificity. Western blot analysis...
To describe our experience with pediatric laparoscopic nephrectomy (LN) and laparoscopic nephroureterectomy (LNU) for giant hydronephrosis.A retrospective review was conducted of all pediatric patients undergoing a transperitoneal LN or LNU. Five of these patients had giant hydronephrosis in a nonfunctioning kidney. Because of chronic infection and the massive nature of hydronephrosis, the system...
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