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Background/Aims: Interferons have been used to treat chronic viral hepatitis, due to their antiviral properties. However, interferons are now recognized also to inhibit collagen production. Since fibrosis has been associated with liver damage and dysfunction, the effects of interferon-α 2b on biliary obstruction-induced fibrosis were investigated.Methods: Extrahepatic cholestasis was...
Background/Aim: Several drugs have been tested for the treatment of hepatic cirrhosis induced by various etiologic agents. Although interferon (IFN)α-2a has mostly been used to treat viral hepatitis, its antifibrogenic properties remain to be established.Methods: An experimental model of cholestasis-induced cirrhosis was used to test the effect of IFNα-2a. Cirrhosis was induced in rats via ligation...
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