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Background/Aims: Hyporesponsiveness to vasoconstrictors in portal hypertension has been shown to involve increased production of nitric oxide in large arteries in vitro. Small arteries (diameter 50-500 μ) are partly responsible for peripheral resistance and probably have different regulatory mechanisms from large arteries. The purpose of this study was to investigate the hyporeactivity of small mesenteric...
Background/Aims: We have recently demonstrated that heme oxygenase-1 is upregulated in splanchnic organs of portal hypertensive rats. In the present study, we assessed whether heme oxygenase enzymatic activity is increased in splanchnic organs of portal hypertensive rats, and the relative contribution of heme oxygenase and nitric oxide synthase to the vascular hyporeactivity in portal hypertension...
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