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Background/Aims: Liver stellate cell proliferation and differentiation into myofibroblast-like cells is related to the development of liver fibrosis. Several cytokines, including interferons, regulate liver stellate cell proliferation and phenotypic modulation. Recent studies indicate that human liver stellate cells express the α-isotype of actin, specific to smooth muscle cell differentiation. We...
Aims/Methods: In the human liver, α-smooth muscle actin (ASMA) is present in smooth muscle of the vasculature, perisinusoidal cell (Ito cells), and myofibroblasts derived from perisinusoidal cells. In this study, we investigated ASMA-positive stromal cells and their relation to tumor fibrosis in 50 cholangiocarcinomas, 30 hepatocellular carcinomas, and 57 metastatic liver carcinomas.Results: Tumor...
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