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Unilateral injection of 25 ng of muscimol into the rat substantia nigra parts reticulata induced contralateral circling. Circling induced by 25 ng of muscimol was increased by simultaneous administration of 1 μg of Δ 9 -tetrahydrocannabinol and abolished by 10 μg. Previous experiments have shown that Δ 9 -tetrahydrocannabinol enhances muscimol-induced catalepsy in the globus pallidus. These results identify another brain area in which synergism between Δ 9 -tetrahydrocannabinol and muscimol can occur and show that Δ 9 -tetrahydrocannabinol can enhance an excitatory as well as an inhibitory GABAergic motor effect. The data support the hypothesis that cannabinoids can facilitate transmission along central γ-aminobutyric acid (GABA) releasing pathways.