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We have recently shown that freshly isolated astrocytes from the mouse brain express mRNA for the L-channel gene Ca v 1.3 to at least the same degree (per mg mRNA) as corresponding neurons. The amount of extracellular Ca 2+ actually entering cultured astrocytes by its opening is modest, but due to secondary Ca 2+ -mediated stimulation of the ryanodine receptor (RyR) the increase...
Selective serotonin reuptake inhibitors, such as fluoxetine, have recently been shown to exert anti-inflammatory and immunosuppressive effects. Although the effects on cytokine secretion, proliferation and viability of T lymphocytes have been extensively characterized, little is known about the mechanism behind these effects. It is well known that Ca2+ signaling is an important step in the signaling...
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