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Calcium ions and cyclic adenosine monophosphate (cAMP) are virtually ubiquitous intracellular signaling molecules in mammalian cells. This paper will focus on the cross-talk between Ca 2+ and cAMP mobilizing signaling pathways and summarize the underlying molecular mechanisms. Subsequently, workings of adenohypophyseal corticotrope cells will be reviewed to highlight the physiological relevance...
Crosstalk between intracellular signalling pathways is a functionally important and widespread phenomenon in cell physiology across phyla. In the salivary gland of the blowfly, serotonin induces fluid secretion via parallel activation of both the InsP 3 /Ca 2+ and the cAMP/PKA signalling pathways, which interact on multiple levels. We have determined the molecular identity of a link...
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