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Poly-l-lysine with 40% of the -amino groups substituted with lactosyl residues facilitated the internalization of lactosylated poly-l-lysine/cDNA complexes into cystic fibrosis (CF) and non-CF airway epithelial cells. It was previously shown that lactosylated poly-l-lysine enhanced the transfer of cDNA into the cell nucleus, resulting in transfection. The cell entry of lactosylated poly-l-lysine/cDNA...
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