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d-serine dehydratase (Dsd) from baker’s yeast is a recently discovered enzyme catalyzing the oxidation of d-serine to pyruvate and ammonia. The reaction depends on the cofactors pyridoxal-5′-phosphate (PLP) and Zn 2+ , featuring a very high selectivity towards the d-enantiomer of the amino acid serine. In humans, altered levels of d-serine in the cerebrospinal fluid (CSF) and blood correlate...
The adenine nucleotide carrier (Ancp) plays an essential role in the metabolism of cellular energy by catalyzing the transport of ADP and ATP across the inner mitochondrial membrane. Previous reports have indicated that mutations in the HANC1 gene, encoding the muscle isoform of human Ancp (HAnc1p), are directly involved in several diseases, including autosomal dominant progressive external ophthalmoplegia...
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