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Telomerase is a key participant of telomere length maintaining system in the majority of eukaryotes. It synthesizes telomere repeats at the 3′-end of telomere DNA using its own RNA template. The Saccharomyces cerevisiae telomerase complex contains the reverse transcriptase (Est2) and RNA subunits (TLC1), as well as number of additional proteins among which Est3 is known to be essential for telomere...
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