This work demonstrated a new method to synthesize the functional hybrid material composed of reduced graphene oxide and Au/Ag core-shell nanorods (rGO-Au@AgNRs). The hybrid material can detect rhodamine-6G (R6G) with an enhancement factor (EF) up to (5.0±0.2)×108, 4 fold higher than that of the rGO-AuNRs. Comparing with SERS-active substrate Au@Ag (without rGO), the Raman intensity of R6G on the rGO-Au@AgNRs has significant enhancement, especially at the Raman peak of 611cm−1, around 17 times. We also use rGO-Au@AgNRs to monitor the pesticide thiram at a low level ∼10−7M and RSD 7.5% at the 561cm−1. The limit of detection (LOD) of thiram using rGO-Au@AgNRs was low to 5.12×10−3μM, which suggested that the rGO-Au@AgNRs has potential applications in the detection of environment pollutants etc.