Water chemical data from the Botucatu Sandstone aquifer in the Sao Paulo State part of the Parana Basin, Brazil, was evaluated using geochemical methods and two statistical analyses: cluster analysis and factor analysis. The results were used to develop a conceptual geochemical model, in which three geochemical regions were identified, and their chemical behavior was modeled. The characteristic chemicals, changing from the recharge area to the center of the basin, are: SiO 2 -(HCO 3 - and Ca 2 + )-(Na + , CO 3 2 - , and SO 4 2 - ). The distribution of the chemicals is interpreted as controlled by different water-rock interaction processes in the different regions. In the recharge area, dissolution of alkali-feldspar minerals in the sandstone is the main reaction observed; in the mid-section of the basin, calcite dissolution results in high calcium and bicarbonate concentration; in the center of the basin, leakage from underlying layers becomes the governing factor.