The objective of this research was to encapsulate turmeric extract as a water-insoluble bioactive material by nanostructured lipid carrier (NLC). Turmeric extract loaded NLC (T-NLC) was produced by high shear homogenization method. The average size of T-NLC was 112.4nm and it showed good physical stability, and a sustained release pattern. Higuchi model fit in vitro release of turmeric extract from NLC the best. The antioxidant activity of T-NLC was significantly higher than free turmeric extract. The results of microbiological tests by agar-dilution method showed that NLC had higher antimicrobial activity than free turmeric extract against all examined gram negative bacilli microorganisms. The results indicate that T-NLC can be used in food products with high functional effects.