The thermal fluidic system (TFS), a type of two-phase device, has recently attracted significant attention in mechatronic system cooling. The aim of this study is to use magnetic nanofluid (MNF) with magneto-hydrodynamics (MHD) to enhance the thermal performance of a miniature TFS. The MNF used for the primary working fluid (WF) can be prepared from fine ferromagnetic particles of iron ferrite using a chemical co-precipitation technique. Based on the design of local electromagnetic fields, a transient Lorentz force can be induced within the MNF-based channel flow and thermal convection in MNF can then be actively enhanced. In this study of a novel TFS, the highest thermal performance showed a 41.82±0.01% enhancement. This study not only shows an effective technique for identifying TFS dynamics, but also provides valuable suggestions for cooling system designs using regular heat transportation.