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Levetiracetam (LEV) is a novel antiepileptic drug (AED) with efficacy against a wide range of seizures types. The aim of this observational study was to assess its effectiveness in patients with mental retardation and refractory epilepsy. Sixty-four patients were started on adjunctive LEV after a 3-month baseline. LEV was initially dosed at 250mg daily and increased by 250mg every 2 weeks thereafter...
This study analyzed the occurrence of learning disability (LD) in adults with childhood-onset epilepsy and the impact of LD on medical and social outcome. Any LD occurred in 76%: in 57% of mentally normal (IQ>85), in 67% of mentally near-normal (IQ=71–85), and, self-evidently, in all mentally retarded (IQ<71) adults. Half of the patients (51%) with LD had mental retardation. In multivariate...
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