Spherically focused, high frequency (30-50MHz) ultrasonic imaging transducers are fabricated using poly(vinylidene) difluoride (PVDF) film and a membrane deflection technique that is compatible with CMOS microelectronics fabrication. Micromachined ultrasonic transducers with 0.75-2.00mm-diameter apertures and f-numbers of 1.30-2.45 are fabricated and characterized. The transducers exhibit focused radiation patterns with 50μm axial resolution and 51-92μm lateral resolution and bandwidths of 80-110% around center frequency values. A miniature preamplifier hybrid circuit, which is designed to be mounted within the transducer housing, is fabricated and characterized to reveal a low noise level of 5.3nV/H z . Tissue imaging capabilities of the micromachined ultrasonic transducers are demonstrated through successful imaging of human cadaveric aorta.