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While conducting a gene discovery effort targeted to transcripts of the prevalent and intermediate frequency classes in placenta throughout gestation, we identified a novel member of the TGF-β superfamily that is expressed at high levels in human placenta. Hence, we named this factor `Placental Transforming Growth Factor Beta' (PTGFB). The full-length sequence of the 1.2-kb PTGFB mRNA has the potential...
A homologue of 19kDa signal recognition particle locus (SRP19) was cloned and molecularly characterized in Drosophila melanogaster. It is located in the 65F region of the left arm on the third chromosome, approx. 500bp 5' of the quemao locus. The SRP19 transcript was determined from cDNA clones, Northern blot analysis, and the 5' rapid amplification of cDNA end method. SRP19 was expressed in all the...
Analysis of a 32.8-kb segment of DNA from the rapamycin (Rp) producer, Streptomyces hygroscopicus ATCC 29253, revealed a new type-I polyketide synthase (PKS) cluster consisting of four open reading frames (ORF 1-4), each encoding a single PKS module. The four ORFs are transcribed in the same direction and are flanked by several smaller ORFs (ORF 5-9), which may be related to the PKS cluster. The first...
Zinc-finger proteins of the Cys 2 His 2 type bind DNA-RNA hybrids with affinities comparable to those for DNA duplexes. Such zinc-finger proteins were converted into site-specific cleaving enzymes by fusing them to the FokI cleavage domain. The fusion proteins are active and under optimal conditions cleave DNA duplexes in a sequence-specific manner. These fusions also exhibit site-specific...
We recently cloned the murine 11-cis retinol dehydrogenase gene. A second gene, the murine GCN5L1 gene, was found to be situated upstream of the murine 11-cis retinol dehydrogenase gene. We have isolated and sequenced the complete coding sequence of the murine GCN5L1 gene. The distance between the 3'-end of the murine GCN5L1 gene and the 5'-end of the 11-cis retinol dehydrogenase gene is only 776nt...
The signal recognition particle (SRP) is a ribonucleoprotein composed of a 7SL RNA and six polypeptides. Here we report the results of a series of experiments carried out to define the function of the Yarrowia lipolytica homologue of the 19kDa subunit of mammalian SRP. The YlSEC65 gene product is a 310 amino acid protein. Coimmuneprecipitation of Sec65p and 7SL RNA in Y. lipolytica revealed that these...
A novel toxin (Beta2) and its gene were characterized from a Clostridium perfringens strain isolated from a piglet with necrotic enteritis. At the amino-acid level, Beta2 toxin (27 670Da) has no significant homology with the previously identified Beta toxin (called Beta1) (34 861kDa) from C. perfringens type B NCTC8533 ( Hunter, S.E.C., Brown, J.E., Oyston, P.C.F., Sakurai, J., Titball, R.W., 1993...
Eukaryotic gene targeting by means of gene replacement vectors is often complicated by unwanted plasmid insertion events involving the ends of transforming DNA molecules. These undesirable and often multiple insertions occur both randomly (i.e. non-homologously) and at the targeted locus. By blocking the 3' ends of transforming DNA with 2'3' dideoxynucleotides, we have reduced the frequency of end-mediated...
The circular DNA plasmid, designated pAAT56, has been isolated from strain T88-56 of the Japanese pear pathotype of Alternaria alternata. We determined the complete nucleotide sequence (5354bp) of pAAT56 and mapped its possible open reading frames (ORFs). Three long ORFs, ORF1 (1290bp), ORF2 (1653bp) and ORF3 (690bp), and four smaller ORFs, ORF4 to ORF7 (=<300bp), were predicted from the sequence...
Copper/zinc-containing superoxide dismutase (Cu/Zn SOD) is one of the essential enzymes that protects cells in aerobic conditions. To understand the mechanism of transcriptional regulation of the human Cu/Zn SOD gene, the proximal promoter region of Cu/Zn SOD has been investigated. In a previous study, it was found that transcription factors of the Sp1 and C/EBP family are associated with the expression...
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