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Csn8 is the smallest subunit of the constitutively photomorphogenic 9 (COP9) signalosome (CSN), which consists of eight distinct components. CSN is homologous to the lid subcomplex of the 26S proteasome and is a regulator of the ubiquitin-proteasome pathway. Murine Csn8 is an ortholog of Arabidopsis COP9, which was originally identified as a key regulator of photomorphogenic development. CSN is essential...
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