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In a recent paper written with the purpose of shedding light on the question of whether genomic GC levels are related to temperature in vertebrates, Ream et al. [Mol. Biol. Evol. 20 (2003) 105] offered an analysis of two sets of homologous genes: those coding for α-actin and lactate dehydrogenase-A (LDH-A). The conclusion was that ''there is no consistent relationship between adaptation temperature...
A recent paper by Belle et al. (J. Mol. Evol. 55 (2002) 356) reported an analysis of mean GC 3 (the GC level of third codon positions) and standard deviations of GC 3 of vertebrate genomes as related to body temperature, and concluded that ''the thermal stability hypothesis does not appear to explain the general patterns of composition'', apparently contradicting a previous working...
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