The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
L1 retrotransposons have been the major driver of structural variation of the human genome. L1 insertion polymorphism (LIP)-mediated genomic variation can alter the transcriptome and contribute to the divergence of human phenotypes. To assess this possibility, a genome-wide association study (GWAS) including LIPs is required. Toward this ultimate goal, the present study examined linkage disequilibrium...
Lung cancer remains the most prevalent malignancy worldwide. Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphic genes. Several metabolic enzymes are currently under investigation for their possible role in lung cancer susceptibility, including members of the cytochrome P450 (CYP) superfamily. The aim of this work was to identify the correlation between CYP1A1...
Mutations and polymorphisms in the RET gene are a major cause of Hirschsprung disease (HSCR). Theoretically, all true heterozygous patients with a new manifestation of a genetically determined disease must have parents with a genetic mosaicism of some extent. However, no genetic mosaicism has been described for the RET gene in HSCR yet. Therefore, we analyzed families with mutations in the RET gene...
Oxygen availability has been a major force in shaping the physiological evolution of animals. Under reduced oxygen availability (hypoxia) major changes in gene expression are mediated by hypoxia-inducible factors (HIF alphas). Tetrapods have three hif alpha genes, whereas zebrafish (Danio rerio) and other cyprinids have six due to a teleost lineage-specific genome duplication. We studied the transcriptional...
As a key component of the Toll signaling pathway, Tube plays central roles in many biological activities, such as survival, development and innate immunity. Tube has been found in shrimps, but has not yet been reported in the crustacean, Eriocheir sinensis. In this study, we cloned the full-length cDNA of the adaptor Tube for the first time from E. sinensis and designated the gene as EsTube. The full-length...
•MiR-145 was downregulated in patients with HCC.•The restoration of miR-145 significantly inhibits cell proliferation and reduces cell migration in HCC cells.•MiR-145 can induce cell cycle arrest and apoptosis in HCC cells, possibly through inhibiting expression of multiple genes along the IGF axis.•MiR-145 may be a potential therapeutic target for HCC.
We isolated deoxycholate-resistant mutants from Vibrio parahaemolyticus RTM34, which lacks four multidrug efflux transporters belonging to the resistance nodulation cell division (RND) family. RTM34 showed sensitivity to many antimicrobial agents such as cholate and deoxycholate. Deoxycholate-resistant mutants from RTM34 have elevated resistance to not only deoxycholate, but also antibiotics, disinfectants,...
Telomerase is a reverse transcriptase ribonucleoprotein that maintains the ends of linear chromosomes. This enzyme plays a major role in cell processes like proliferation, differentiation and tumorigenesis, being associated with aging and survival of species. In this study, the gene coding for TERT (Telomerase Reverse Transcriptase) of two commercial fish species, European hake (Merluccius merluccius)...
The alteration in the epigenome forms an interface between the genotype and the environment. Epigenetic alteration is expected to make a significant contribution to the development of cardiovascular disease where environmental interactions play a key role in disease progression. We had previously shown that global DNA hypermethylation per se is associated with coronary artery disease (CAD) and is...
The α-tocopherol transfer protein (α-TTP) is a ~32kDa cytosolic protein that plays an important role in the efficient circulation of plasma α-tocopherol in the body, a factor with great relevance in reproduction. The α-TTP gene has been studied in a number of tissues; however, its expression and function in some ovine tissues remain unclear. A previous study from our laboratory has demonstrated α-TTP...
In order to better understand the biological systems that are affected in response to cosmic ray (CR), we conducted weighted gene co-expression network analysis using the module detection method. By using the Pearson's correlation coefficient (PCC) value, we evaluated complex gene–gene functional interactions between 680 CR-responsive probes from integrated microarray data sets, which included large-scale...
Inference of gene regulatory networks (GRNs) is one of the most challenging research problems of Systems Biology. In this investigation, a new GRNs inference methodology, called Entropic Biological Score (EBS), which linearly combines the mean conditional entropy (MCE) from expression levels and a Biological Score (BS), obtained by integrating different biological data sources, is proposed. The EBS...
Gynecomastia is a benign breast enlargement in males that affects approximately one-third of adolescents. The exact mechanism is not fully understood; however, it has been proposed that estrogen receptors and aromatase enzyme activity may play important roles in the pathogenesis of gynecomastia. While many studies have reported that aromatase enzyme (CYP19) gene polymorphism is associated with gynecomastia,...
Whole genome sequencing of six diagnostic brucellaphages, Tbilisi (Tb), Firenze (Fz), Weybridge (Wb), S708, Berkeley (Bk) and R/C, was followed with genomic comparisons including recently described genomes of the Tb phage from Mexico (Tb M ) and Pr phage to elucidate genomic diversity and candidate host range determinants. Comparative whole genome analysis revealed high sequence homogeneity...
•A full-length cDNA library from Siberian tiger fibroblasts has been constructed.•ESTs were deposited in the GenBank from KF896402 to KF896586KF896402KF896403KF896404KF896405KF896406KF896407KF896408KF896409KF896410KF896411KF896412KF896413KF896414KF896415KF896416KF896417KF896418KF896419KF896420KF896421KF896422KF896423KF896424KF896425KF896426KF896427KF896428KF896429KF896430KF896431KF896432KF896433KF896434KF896435KF896436KF896437KF896438KF896439KF896440KF896441KF896442KF896443KF896444KF896445KF896446KF896447KF896448KF896449KF896450KF896451KF896452KF896453KF896454KF896455KF896456KF896457KF896458KF896459KF896460KF896461KF896462KF896463KF896464KF896465KF896466KF896467KF896468KF896469KF896470KF896471KF896472KF896473KF896474KF896475KF896476KF896477KF896478KF896479KF896480KF896481KF896482KF896483KF896484KF896485KF896486KF896487KF896488KF896489KF896490KF896491KF896492KF896493KF896494KF896495KF896496KF896497KF896498KF896499KF896500KF896501KF896502KF896503KF896504KF896505KF896506KF896507KF896508KF896509KF896510KF896511KF896512KF896513KF896514KF896515KF896516KF896517KF896518KF896519KF896520KF896521KF896522KF896523KF896524KF896525KF896526KF896527KF896528KF896529KF896530KF896531KF896532KF896533KF896534KF896535KF896536KF896537KF896538KF896539KF896540KF896541KF896542KF896543KF896544KF896545KF896546KF896547KF896548KF896549KF896550KF896551KF896552KF896553KF896554KF896555KF896556KF896557KF896558KF896559KF896560KF896561KF896562KF896563KF896564KF896565KF896566KF896567KF896568KF896569KF896570KF896571KF896572KF896573KF896574KF896575KF896576KF896577KF896578KF896579KF896580KF896581KF896582KF896583KF896584KF896585KF896586...
Aspergillus niger is usually regarded as a beneficial species widely used in biotechnological industry. Obtaining the genome sequence of the widely used aconidial A. niger SH2 strain is of great importance to understand its unusual production capability. In this study we assembled a high-quality genome sequence of A. niger SH2 with approximately 11,517 ORFs. Relatively high proportion of genes enriched...
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays a critical role in the development and progression of tumors. Various studies evaluating the prognostic value of HIF-1α in patients with lung cancer (LC) remain controversial. To comprehensively and quantitatively summarize the evidence on the effect of HIF-1α expression on the survival of patients with LC, a meta-analysis was...
Bunostomum trigonocephalum and Bunostomum phlebotomum are blood-feeding hookworms of sheep and cattle, causing considerable economic losses to the live stock industries. Studying genetic variability within and among hookworm populations is critical to addressing epidemiological and ecological questions. Mitochondrial (mt) DNA is known to provide useful markers for investigations of population genetics...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.