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Inguinal hernia is a common surgical disease, majority of which are indirect inguinal hernia (IIH). A positive family history has indicated that genetic factors play important roles in the IIH development. To date, genetic causes and underlying mechanisms for inguinal hernia remain largely unknown. During the embryonic development, GATA transcription factor 6 (GATA6) plays an essential role. Mutations...
MAGEL2 (melanoma antigen-like gene 2) is essential for circadian function, metabolism and reproduction in mammals. This study was conducted to investigate transcriptional regulation and functional importance in the placenta of porcine MAGEL2. Quantitative real-time PCR showed that MAGEL2 was highly expressed in porcine hypothalamus, pituitary and placenta (P<0.05). The gene was down-regulated in...
Cofilins (CFL), including CFL1 and CFL2, are members of the family of actin-binding proteins in eukaryote. CFL2 is predominantly expressed in mammalian skeletal muscle and heart and is important to muscle fiber formation and muscular regeneration. To study transcriptional regulation of porcine CFL2, a 2.5kb upstream sequence starting from the major CFL2 transcriptional start site was cloned by genome...
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