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Natural antisense transcripts, because of their potential to form double-stranded RNA (dsRNA) molecules, recently emerged as a mechanism acting on eukaryotic gene regulation at multiple levels. CHRNA3 and CHRNA5, coding for α3 and α5 subunits of the neuronal nicotinic acetylcholine receptor, have been reported to overlap at their 3′ends in human and bovine genomes. In the present paper, four CHRNA3...
We report here on the in vitro and in silico characterization of the organization of the human complexin 2 (CPLX2) gene. This encodes for a protein of 134 amino acid residues, contains five exons, is localized on human chromosome 5q35.3, and spans more than 87 kb. We performed in silico analysis of the CPLX2 5′ untranslated region (UTR) and propose an alternative variant of the gene transcript. Compared...
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