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Bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly which affects 0.5–2% of the population. It can be associated with other cardiac congenital lesions such as aortic aneurysms or aortic coarctation. Some genetic abnormalities have been suggested as the underlying cause of BAV and aortic root dilatation, but no clear genetic substrate and no specific pathogenic gene variant have...
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