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There is evidence of multiple copies of the FSHD Region Candidate Gene 1 (FRG1) in humans. Analysis of human FRG1 ESTs showed many of them to be non-processed pseudogenes dispersed throughout the genome. To determine when the amplification of FRG1 occurred, we used a PCR-based approach to identify FRG1 sequences from great apes, chimpanzee, gorilla and orang-utan, and an Old World monkey, Macaca mulatta...
Molecular evolutionary analyses of mammalian ribonucleases have shown that gene duplication events giving three paralogous genes occurred in ruminant ancestors. The enzymes of the bovine species encoded by these genes, isolated from pancreas, brain and seminal vesicles, present similar enzymological properties but distinct structural features. In other ruminant species, genomic sequences orthologous...
The highly heterogeneous rat hemoglobin system was investigated at the gene level. Two regions of the α-like globin gene cluster from a Wistar rat were isolated. Four λ Dash recombinant clones carrying rat α-like globin genes were localized on two distinct gene regions. A region of approximately 16kb was found to contain the 5'- II α1-ψθ1-3' loci, and another of approximately 24kb the...
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