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Prolonged dietary Na + depletion and chronic administration of adrenal steroids increase steady-state mRNA levels of the γ subunit of the epithelial sodium channel (γENaC) in rat colon. This increase correlates with a marked increase in transepithelial Na + transport and is thought to occur via transcriptional regulation. To begin to evaluate these mechanisms in detail, we determined...
Embigin is a transmembrane glycoprotein belonging to the immunoglobulin superfamily, which is preferentially expressed in early stages of mouse embryogenesis and enhances integrin-mediated cell-substratum adhesion. The mouse embigin gene, which we cloned, spanned more than 50kb, in which nine exons were present. All exons contained protein-coding sequences. Each of the two immunoglobulin domains was...
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