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The role of βAPP gene transcription and promoter regulation in modifying amyloid β-peptide (Aβ) levels is not well understood. Increased production of Aβ or changes in Aβ 42 /Aβ 40 ratio by fibroblasts occurs in the presence of mutant presenilin or βAPP alleles in familial Alzheimer's disease subjects. Both βAPP mRNA and Aβ levels are increased in trisomy 21. The APP gene...
Previous studies demonstrated that the -82 to +87 nucleotides (nt) 5'-upstream region of the chicken apolipoprotein (apoAI) gene are necessary for maximum reporter chloramphenicol acetyl transferase (cat) gene activation in chicken hepatocarcinoma (LMH) cells [Bhattacharyya, N., Chattapadhyay, R., Oddoux, C., Banerjee, D., 1993. Characterisation of the chicken apolipoprotein A-I gene 5'-flanking region...
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