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It has been claimed that proteins with more interacting partners (hubs) are structurally more disordered and have a slow evolutionary rate. Here, in this paper we analyzed the evolutionary rate and structural disorderness of human hub and non-hub proteins present/absent in protein complexes. We observed that both non-hub and hub proteins present in protein complexes, are characterized by high structural...
Recombinant DNA technology largely depends upon Escherichia coli plasmid construction via restriction enzyme digestion and DNA ligation. Overlap extension PCR is another simple technique for constructing recombinant DNA but is not commonly used. This is likely due to the inefficiency of fusion after the annealing of overlaps that are generally designed from authentic sequences in the DNA fragments...
OrcPI is a class B MADS-box gene of Orchis italica (Orchidaceae), homologous of the PISTILLATA/GLOBOSA gene isolated in Arabidopsis and Antirrhinum. Its role in determining petals and stamens is conserved in orchids, where it seems to be involved also in other functions, such as flower longevity and ovary development. The present study reports the genomic characterization of the OrcPI locus in O....
The similarities and differences in the chloroplast genes editing patterns of four species from one family (and two genera), which is the first-ever attempt at comparison of such data in closely related species, is discussed. The effective use of the chloroplast genes editing patterns in evolutionary studies, especially in evaluating the kinship between closely related species, is thereby proved....
RAGE is a member of the immunoglobulin superfamily of cell surface molecules playing key roles in pathophysiological processes, e.g. immune/inflammatory disorders, Alzheimer's disease, diabetic arteriosclerosis and tumourigenesis. In humans 19 naturally occurring RAGE splicing variants resulting in either N-terminally or C-terminally truncated proteins were identified and are lately discussed as mechanisms...
Nucleosome packaging influences many aspects of DNA metabolism such as replication, repair and transcription, and via this link likely has further downstream effects on genome stability. The instability and expansion of repetitive sequences is associated with at least 42 human diseases, yet the molecular conditions contributing to repeat instability have remained largely undetermined. Previously we...
Short and long retroposons, or non-LTR retrotransposons (SINEs and LINEs, respectively) are two groups of interspersed repetitive elements amplifying in the genome via RNA and cDNA-mediated reverse transcription. In this process, SINEs entirely depend on the enzymatic machinery of autonomous LINEs. The impact of retroposons on the host genome is difficult to overestimate: their sequences account for...
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