First reports on the application of deep brain stimulation of the Nucleus basalis of Meynert reported feasibility and safety of the intervention in patients with Alzheimer’s disease. However, clinical effects vary and the mechanisms of actions are still not well understood.We studied preoperative T1-weighted MR images of ten patients with Alzheimer’s disease and correlated the clinical outcome with volumetric differences in a vertex-based analysis, controlling for age, sex and the total intracranial volume. Clinical assessments, 12months after the intervention, included the Alzheimer’s Disease Assessment Scale with its subitems for cognition and memory as well as the mini mental status examination.A fronto-parietal pattern including significant clusters covering the inferior and superior parietal gyrus, the precuneus, the superior and middle frontal gyrus were found to be correlated with a beneficial outcome.Our results support the assumption, that patients with less advanced morphological changes may benefit more from deep brain stimulation of the Nucleus basalis of Meynert. Furthermore, we conclude that positive effects are mediated by a preserved fronto-parietal interplay.