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Mercury and its derivatives are known to constrict vascular smooth muscle cells. However, little is known about the role of endothelial cells in mercury-induced vasoreactivity. Using isolated, norepinephrine preconstricted rat aorta and pulmonary artery rings with intact endothelium, we demonstrate that mercury chloride (HgCl 2 ) induces an endothelial-dependent vasorelaxation which was totally...
To evaluate the impact of dietary exposure to endocrine disrupting chemicals (EDCs) during the sensitive period of brain sexual differentiation, maternal Sprague-Dawley rats were fed three representative chemicals, methoxychlor (MXC; 24, 240, and 1200ppm), genistein (GEN; 20, 200, and 1000ppm), or diisononyl phthalate (DINP; 400, 4000, and 20,000ppm), from gestational day 15 to postnatal day 10. Soy-free...
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