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Fumonisin B 1 (FB 1 ), a mycotoxin produced by Fusarium verticillioides and related fungi infests corn and other cereals, and causes a variety of toxic effects in different mammalian species. Hepatotoxicity is a common toxic response in most species. The cellular responses of FB 1 involve inhibition of ceramide synthase leading to accumulation of free sphingoid bases and a...
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