North Evoikos Gulf, Greece, constitutes a landlocked, epicontinental and semi-enclosed basin, connected to the central-west Aegean Sea through a strait, probably not allowing full exchange of intermediate and deep water masses. Benthic foraminifer analyses were carried out on a Late Quaternary core from the outer shelf of the basin with the aim of tracing palaeoceanographic changes.The benthic foraminifer species percentage per sample was used to calculate two main biological proxies: the Benthic Foraminifer Oxygen Index (BFOI) and Benthic Foraminifer High Productivity (BFHP) proxy estimated by grouping benthic foraminifer taxa which are known to flourish under high Corg flux. The estimated values of BFHP and BFOI were controlled mainly by the abundance of bolivinid species which are generally considered as opportunistic and shallow infaunal species, tolerant to low oxygen conditions. The statistical analysis (Q-mode cluster analysis) singled out four time intervals, each characterized by certain levels of oxygenation and food availability. Time interval 1 (8513–8300calBP) is characterized by a mixed fauna of oxyphilic taxa and taxa that live in suboxic environment, indicating the existence of a relatively eutrophic system with a well-oxygenated sediment–water interface. Time interval 2 (8300–8100calBP) records a deterioration of conditions on sea floor, testified by significant oxygen and biotic diversity decrease. Benthic foraminifer composition in Time interval 3 (8100–7000calBP) depicts environmental conditions still highly variable, yet with faunal indication of more stable conditions than during the previous interval. Finally, the benthic foraminifer assemblage of Time interval 4 (7000–3500calBP) is related to the high food supply and good bottom circulation.The data suggest a strong linkage between the quantity and quality of the organic matter supplies, and the diversity and composition of the benthic foraminifer faunas. Moreover, this study clearly demonstrates that vertical tectonic movements need to be taken into account when reconstructing the late Quaternary palaeoceanography of this region.