In the frame of a systematic study of the activation cross-sections of the proton induced nuclear reactions, excitation functions of the 55 Mn(p,x) 54,52g Mn, 51 Cr and 48 V were measured up to 70MeV. Cross-sections were measured with the activation method using the stacked foil irradiation technique and high resolution γ-ray spectrometry. The experimental data are analyzed and compared to the earlier results and to the prediction of the EMPIRE-3 as well as the TALYS theoretical model code in the TENDL-2012 library. From the measured cross-section data integral production yields were calculated. Practical applications of the cross-sections e.g. for thin layer activation are discussed.